Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists | Eddy Sotelo's Research Group - USC

Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A₁ Antagonists

Cristina Val, Carlos Rodríguez-García, Rubén Prieto-Díaz, Abel Crespo, Jhonny Azuaje, Carlos Carbajales, Maria Majellaro, Alejandro Díaz-Holguín, José M. Brea, Maria Isabel Loza, Claudia Gioé-Gallo, Marialessandra Contino, Angela Stefanachi, Xerardo García-Mera, Juan C. Estévez, Hugo Gutiérrez-de-Terán and Eddy Sotelo

J. Med. Chem. 2022, 63, 2091-2116.

https://doi.org/10.1021/acs.jmedchem.1c01636