Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists

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Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists

Ana Mallo-Abreu, Rubén Prieto-Díaz, Willem Jespers, Jhonny Azuaje, Maria Majellaro, Carmen Velando, Xerardo García-Mera, Olga Caamaño, José Brea, María I. Loza, Hugo Gutiérrez-de-Terán, and Eddy Sotelo

Journal of Medicinal Chemistry, 2020, 63, 7721-7739. https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00564